In conective

Keywords: connective tissue disease, types, symptoms, causes, autoimmune diseases, genetic diseases, marfan syndrome, lupus, scleroderma, polymyosistis, dermatomyositis, rheumatoid arthritis, ehlers-danlos syndrome, osteogenesis imperfecta, sjögren's syndrome, mary anne dunkin
Description: Learn more from WebMD about connective tissue disease, including symptoms and causes of various forms.

Some connective tissue diseases -- often called heritable disorders of connective tissue (HDCTs) -- are the result of changes in certain genes. Many of these are quite rare. Following are some of the more common ones.

Ehlers-Danlos syndrome (EDS). Actually a group of more than 10 disorders, EDS is characterized by over-flexible joints, stretchy skin, and abnormal growth of scar tissue. Symptoms can range from mild to disabling. Depending on the specific form of EDS, other symptoms may include:

Epidermolysis bullosa (EB). People with EB have skin that is so fragile that it tears or blisters as a result of a minor bump, stumble, or even friction from clothing. Some forms of EB may involve the digestive tract, the respiratory tract, the muscles, or the bladder. Caused by defects of several proteins in the skin, EB is usually evident at birth.

Marfan syndrome . Marfan syndrome affects the bones, ligaments, eyes. heart, and blood vessels. People with Marfan syndrome tend to be tall and have extremely long bones and thin "spider-like" fingers and toes. Other problems may include eye problems due to abnormal placement of the eye lens and enlargement of the aorta (the largest artery in the body), which can lead to a fatal rupture. Marfan syndrome is caused by mutations in the gene that regulates the structure of a protein called fibrillin-1.

Osteogenesis imperfecta . Osteogenesis imperfecta is a condition of brittle bones, low muscle mass, and lax joints and ligaments. There are several types of this condition. Specific symptoms depend on the specific type and may include:

The disease occurs when a mutation in two genes responsible for type 1 collagen reduces the amount or quality of the protein. Type 1 collagen is important to the structure of bone and skin.

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