Ninds library

Keywords: molecular libraries, roadmap research, par-08-024, funding opportunity imaging, molecular, molecular libraries and imaging, molecular librairies research, benchmarks for molecular libraries research, research agenda for molecular libraries, molecular libraries research agenda,assay, ninds
Description: molecular libraries Research Web

  The Program that this Announcement describes is one component of the NIH Roadmap Molecular Libraries and Imaging Initiative.  It provides $100K of funding in Year 1 (via the R21 mechanism) to develop and characterize assays to novel targets, pathways and cellular phenotypes that can be miniaturized and automated.  The objective of the Program is to develop assays that can be used to identify small molecule interactions via high-throughput screening (HTS) of small molecular compound libraries, and to chemically optimize these active compounds as molecular probes.  For this reason, the Program provides rapid “Fast-Track” access, and $25K of additional funding, for HTS-ready assay projects that enter the Roadmap Molecular Library Screening Center Network (MLSCN) in Year 2 of the award.

All applications should provide a rationale for how the availability of a small molecule molecular probe would add a pharmacological dimension to their work that is not currently possible.  In addition, Investigators should define the attributes to be captured in the design of this probe, and provide a plan for developing and characterizing assays that could be used to identify small molecules with essential probe attributes from a large diversity collection of >300,000 small molecules.  Emphasis will be placed on the screening of targets for which selective and potent small molecule modulators are not currently available.

The overall goal of the Roadmap Molecular Library Initiative is to promote the development of small molecule pharmacological tools, and to also facilitate the creation of a PubChem database matching biological assays (for targets, pathways or phenotypes) to small molecules that have activity in these assays.  This is being accomplished through the creation of the MLSCN. a national network of 10 high-throughput Screening Centers. 

  1. The NIH accepts probe development projects for assignment to the MLSCN Centers that consist of HTS-ready primary screening assays
  2. secondary hit validation assays and counter-screening assays used to test for probe attributes not identified in the primary screening assay.  These Centers are resourced to screen assays against a small molecule compound collection assembled for this purpose, the Molecular Libraries Small Molecule Repository (MLSMR). 
  3. The Centers then validate the small molecule “hits” identified in the screen
  4. collaborate with the assay provider to perform counter-screening
  5. and then apply computational and synthetic medicinal chemistry approaches to optimize promising hit structures.

The Assay Development for HTS Program described by PAR-08-024 provides the funding necessary to translate assays from the lab bench into formats that can be used by the MLSCN Centers, and thus acts to promote the first necessary step required for molecular probe development. 

It is expected that 40-50 assay development projects will be funded (for $8 million), in response to two receipt dates each year for the Assay Development for HTS Program.

  • Notice of Opportunity for Fast Track Entry of  Assay Projects for High Throughput Screening into the NIH Roadmap Molecular Libraries Probe Production Centers Network

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