Zolpidem tattrate



Keywords: zolpidem tartrate, pharmacology, half life, pharmacokinetics, contraindications
Description: Professional guide for Zolpidem Tartrate. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.

Mechanism is unknown, but may involve subunit modulation of the GABA A receptor chloride channel macromolecular complex.

Rapid absorption from the GI tract. T max is 1.6 h. C max (5 mg tablet) is about 29 to 113 ng/mL; C max (10 mg tablet) is about 58 to 272 ng/mL.

Bioequivalent to oral tablets. Absorption is rapid from the oral mucosa and GI tract. C max following 5 and 10 mg spray is 114 and 210 ng/mL, respectively, with both occurring at a mean T max of 0.9 hours.

Reduces absorption of zolpidem. Administration with food decreased the mean AUC and C max 27% and 58%, respectively, while the mean T max was prolonged 225 h (from 0.8 to 2.6 h). For faster sleep onset, do not administer zolpidem products with or immediately after a meal.






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